The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimers Disease
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چکیده
منابع مشابه
The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer’s Disease
Alzheimer's disease (AD) is an intractable, neurodegenerative disease that appears to be brought about by both genetic and non-genetic factors. The neuropathology associated with AD is complex, although amyloid plaques composed of the beta-amyloid peptide (Abeta) are hallmark neuropathological lesions of AD brain. Indeed, Abeta plays an early and central role in this disease. beta-site amyloid ...
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Since BACE1 was reported as the beta-secretase in Alzheimer's disease (AD) over ten years ago, encouraging progress has been made toward understanding the cellular functions of BACE1. Genetic studies have further confirmed that BACE1 is essential for processing amyloid precursor protein (APP) at the beta-secretase site. Only after this cleavage can the membrane-bound APP C-terminal fragment be ...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2007
ISSN: 1389-2029
DOI: 10.2174/138920207783769512